Articles Tagged with: derma papilla

Hair Cloning

Hair CloningFrom nano-scale biomedical robots to prosthesis that can be controlled by thoughts, contemporary medicine is brimming with new and innovative solutions to some of the world’s most challenging mental, physical, and emotional issues. In the field of hair restoration, equally exciting advances are being made toward hair cloning, an advanced treatment protocol that experts hope will someday be able to reverse the signs of androgenetic alopecia (pattern baldness) in men and women.

Can Surgeons Clone Hair?

Presently, hair cloning is not available as a treatment for hair loss. As noted by researchers at Columbia University, follicular units present a unique challenge because they are complex and difficult to duplicate in vitro (in a laboratory). Nevertheless, researchers are resolute in their pursuit of a procedure that will effectively clone hair to mask the signs of loss.

To accomplish this, researchers turn to the small nipple-like structures that channel blood, oxygen, and nutrients into hair follicles, called derma papilla (DPs). In a paper titled Follicular Cell Implantation: An Emerging Cell Therapy for Hair Loss, Drs. Jeffrey Teumer and Jerry Cooley explain that these structures have an inductive property that might enable them to produce additional hair follicles when cultivated in vitro.

4 Hair Cloning Techniques

Although science has a ways to go before hair cloning procedures are available, there are at least 4 experimental cloning methods that researchers hope will someday be used to reverse hair loss. Each involves the extraction, manipulation, and implantation of the dermal papilla (DP) cells. These methods include (i):

1. Dermal Papillae Implants (alone)

In this technique, cultivated DPs are implanted in the patient’s scalp. Ultimately, the goal of this procedure is to transform the overlying skin cells into hair follicles. If successful, DP implants have the potential to spur new hair growth in areas where hair follicles have become dormant, miniaturized, or otherwise incapable of sustaining natural hair growth.

2. Dermal Papillae Implants (close proximity to miniaturized follicles)

This technique involves stimulating a pre-existing hair follicle with cultivated DPs, making it significantly different from the DP implant method described above. Scientists believe this method has the potential to produce very natural results, as it capitalizes on follicles that already have the foundational alignment and structure needed to produce a natural look.

3. Proto-Hair Implants

This particular approach has the advantage of producing better hair direction, and thus a more natural look, according to researchers. Proto-Hair implants are created by first cultivating DPs with other skin cells (keratinocytes). Then, the groupings are left until partial hair formation occurs. Finally, the resulting cells are implanted into the scalp.

4. Collagen Matrix Implants

Similar to the Proto-Hair implants described above, this approach to hair cloning implements a collagen matrix to further assist in the cultivation of hair follicles with a healthy and natural orientation. Once cultivated, the follicles are transplanted to restore areas of balding scalp.

Schedule a Hair Loss Evaluation

Our team proudly represents South Florida’s top surgeons, registered nurses, technicians, and technologies. We understand the agony and frustration that accompanies hair loss, and we are committed to helping you develop a customized plan that will create natural results. If you or a loved one is experiencing symptoms of thinning, shedding, or balding, contact the Hair Transplant Institute of Miami to schedule a comprehensive hair loss evaluation.

Contact us online or call our Institute directly at 1.877.443.9070.

Sources:

(i) Teumer J. “Strategies for Follicular Cell Implantation.” Hair Transplant Forum International. Published 2008.

 

New Study: Oxidative Stress Might Cause Pattern Baldness

New Study- Oxidative Stress Might Cause Pattern BaldnessHave you eaten any blueberries lately? If so, hair surgeons say you might be less likely to suffer from androgenetic alopecia, or pattern baldness. According to a new study, certain vitamins and bioflavonoids could enhance the health and functionality of hair follicles, creating long and beautiful hair that will last long into adulthood.

Free Radicals, Oxidative Stress, and Balding. The idea that antioxidant super foods could hold the key to preventing hair loss comes from leading research institutions in the United Kingdom. The Centre for Cutaneous Research at the Queen Mary’s University of London, along with the Farjo Medical Centre and Unilever R&D, have published the findings in an abstract titled Oxidative Stress and Cell Senescence in Androgenetic Alopecia (AGA).

In the report, researchers contrast two separate cultures of hair follicle dermal papilla (DP): One from scalp that has experienced pattern baldness, and one from scalp that exhibits normal hair growth. By contrasting these two selections of DP, researchers were able to make a number of fascinating discoveries:

1. The derma papilla (DP) of balding scalp exhibited higher levels of reactive oxygen species (ROS).

ROS molecules are a special type of free radical that is sometimes produced when the body metabolizes oxygen. As professor of nutrition at Tufts University, Dr. Jeffrey Blumberg has dedicated his professional career to the study and science of free radicals, oxidation, and cell damage. He explains:

“While the body metabolizes oxygen very efficiently, 1% or 2% of cells will get damaged in the process and turn into free radicals,” (i).

Once produced, free radicals are known to swarm the body in search of an extra electron. Numerous studies suggest that this process causes damage on the cellular level, referred to as free radical damage. According to health experts at the Harvard School of Public Health, free radical damage may contribute to cardiovascular disease, vision loss, and other chronic conditions (ii). Now, according to researchers in the UK, it seems free radicals might also lead to pattern baldness by damaging hair follicles.

2. Higher levels of ROS corresponded to decrease cell motility.

Cell motility refers to the ability of body cells to naturally reproduce in a dynamic fashion. Motility is vital for wound healing, tissue regeneration, a number of other important biological functions. When comparing DP cultured from balding scalp to that of normal scalp, researchers found cell motility to decrease as oxygen levels increased, indicating that increased ROS might significantly impair the DP’s ability to support healthy long-term hair growth.

3. DP from balding scalp exhibits higher levels of cell senescence.

Cell senescence occurs when a cell is alive but no longer able to divide and proliferate. As cell senescence increases, the ability of the hair follicle to support natural hair growth decreases.

As a result of the 3 main findings above, researchers now believe “oxidative stress may exacerbate the onset of androgenetic alopecia [pattern baldness],” (iii).

This exclusive health report has been published by the Hair Transplant Institute of Miami. For additional information or appointment requests, please call toll-free 1-877-443-9070.

Sources:

(i) “How Antioxidants Work.” WebMD. Accessed 8 July 2013.

(ii) “Antioxidants: Beyond the Hype.” Harvard School of Public Health. Accessed 8 July 2013.

(iii) “Oxidative Stress and Cell Senescence in Androgenetic Alopecia (AGA)”

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